In a city devastated by an infection of reanimated dead who spread this condition by biting the living, the city has been walled off and isolated from the rest of the world until a survivor presumably immune to the infection will try to escape the dangers of this society post apocalyptic that coexists with these monsters in very peculiar ways.
Primatologist Davis Okoye shares an unshakable bond with George, the extraordinarily intelligent, silverback gorilla who has been in his care since birth. But a rogue genetic experiment gone awry mutates this gentle ape into a raging creature of enormous size. To make matters worse, it’s soon discovered there are other similarly altered animals. As these newly created alpha predators tear across North America, destroying everything in their path, Okoye teams with a discredited genetic engineer to secure an antidote, fighting his way through an ever-changing battlefield, not only to halt a global catastrophe but to save the fearsome creature that was once his friend.